◀ Back to ILK

ILK — NOS2

Text-mined interactions from Literome

Tan et al., J Biol Chem 2002 : Inhibition of ILK activity by dominant negative ILK or a highly selective small molecule ILK inhibitor, in epithelial cells or LPS stimulated J774 cells and murine macrophages, resulted in inhibition of iNOS expression and NO synthesis ... Similarly, ILK inhibition suppressed the LPS stimulated iNOS promoter activity ... Mutation of the NF-kappaB sites in the iNOS promoter abolished LPS- and ILK mediated regulation of iNOS promoter activity ... We conclude that ILK can regulate NO production in macrophages by regulating iNOS expression through a pathway involving PKB/Akt and NF-kappaB
Tsou et al., J Cell Biochem 2010 : TNF-alpha mediated iNOS expression was attenuated by integrin linked kinase (ILK) inhibitor ( KP392 ) and siRNA