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BMP7 — GNRH1
Text-mined interactions from Literome
Otani et al., J Endocrinol 2009
:
Treatment with BMP2 and BMP4 had no effect on
Gnrh mRNA expression ; however,
BMP6 and BMP7 significantly
increased Gnrh mRNA expression as well as GnRH production by GT1-7 cells ... Treatment with BMP2 and BMP4 had no effect on Gnrh mRNA expression ; however, BMP6 and
BMP7 significantly
increased Gnrh mRNA expression as well as
GnRH production by GT1-7 cells ... Considering that BMP6 and BMP7 increased the expression of alpha1E-subunit of R-type calcium channel ( Cacna1e ), which is critical for GNRH secretion, it is possible that BMP6 and
BMP7 directly
stimulate GNRH release by GT1-7 cells
Takeda et al., Mol Cell Endocrinol 2012
(MAP Kinase Signaling System) :
Here, we describe a functional link between BMP-6 and
BMP-7 signals and FSH transcriptional activity
induced by
GnRH using mouse gonadotrope LßT2 cells