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HGF — SMAD4

Text-mined interactions from Literome

Gupta et al., J Cell Sci 2000 : To determine whether the effect of HGF occurs through known mediators which act downstream of the BMP-2/ALK3 complex, we examined the effect of HGF on BMP-2 induced Smad1 phosphorylation, Smad1/Smad4 complex formation, and Smad1 nuclear translocation
Yang et al., Am J Pathol 2003 (Fibrosis) : To decipher the mechanism underlying HGF antagonizing TGF-beta1 's action, we examined the effects of HGF on TGF-beta1 mediated Smad signaling ... HGF neither inhibited Smad-2/3 phosphorylation and their association with Smad-4 induced by TGF-beta1, nor significantly affected inhibitory Smad-6 and -7 expression and cellular abundance of Smad transcriptional co-repressors in NRK-49F cells
de Caestecker et al., Genes Dev 1998 : We demonstrate here that HGF and EGF, which signal through RTKs, can also mediate SMAD dependent reporter gene activation and induce rapid phosphorylation of endogenous SMAD proteins by kinase ( s ) downstream of MEK1