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IL13 — STAT3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT3 → IL13 (increases) Doucet et al., Oncogene 2000*
  Evidence: the constitutive phosphorylation of STAT3 was observed repeatedly in tumor myo®bro- blasts (Figure 6f), but only occasionally in normal ®broblasts (Figure 6e). In the latter cells, IL-4 and IL- 13 induced (Figure 6d) or increased (Figure 6e) the tyrosine phosphorylation of STAT3, whereas in tumor myo®broblasts the two cytokines only caused an increase in the phosphorylation of STAT3 (Figure 6f).

Text-mined interactions from Literome

O'Brien et al., J Biol Chem 1999 : STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130 utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone
Umeshita-Suyama et al., Int Immunol 2000 : Expression of IL-13R alpha 1 evoked STAT3 activation by IL-4 and IL-13, and in stimulated human B cells, on which IL-13R alpha 1 was highly expressed, IL-4 and IL-13 induced STAT3 activation
Doucet et al., Eur J Immunol 2002 (Inflammation) : Treatment with JAK3 inhibitors blocks IL-13 induced phosphorylation of JAK2, TYK2 and STAT3 , but not of JAK1 and STAT6
Xu et al., Mol Cell Biol 2003 : Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen activated protein kinase mediated serine 727 phosphorylation of Stat1 and Stat3 ... We found that IL-13 induced a time dependent serine phosphorylation of both Stat1 and Stat3 , detectable at 15 min after IL-13 treatment ... SB202190, a p38 MAPK-specific inhibitor, markedly inhibited IL-13 induced Stat1 and Stat3 serine phosphorylation as well as DNA binding
Xu et al., J Biol Chem 2004 : Inhibition of PKCdelta activation by rottlerin also markedly attenuated IL-13 induced Stat3 DNA binding activity
Bhattacharjee et al., J Immunol 2006 : IL-13 stimulated the phosphorylation of Stat3 on both Tyr705 and Ser727 ... In this study we show that IL-13 induces the association of PKCdelta with Stat3, not with Stat1, and is required for Stat3 Ser727 phosphorylation
Chiba et al., J Smooth Muscle Res 2009 (Asthma...) : In contrast, neither IL-13 nor IL-4 induced phosphorylation of STAT3
Ozawa et al., Journal of ophthalmology 2011 : In innate chorioretinal inflammation, interleukin-6 family ligands induce STAT3 activation in photoreceptors, which causes UPS mediated excessive degradation of the visual substance, rhodopsin
Murata et al., J Immunol 1996 (Colonic Neoplasms) : Both IL-13 and IL-4 induced phosphorylation of IL-4 STAT ( STAT6 ) but not STAT1, STAT3 , or STAT5