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IL22 — STAT3

Pathways - manually collected, often from reviews:

• BioCarta il22 soluble receptor signaling pathway: STATs (STAT3/STAT5A/STAT1/STAT5A/STAT5B/STAT5B) → IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) (modification, collaborate)
  
• BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) → STATS/STATS complex (STAT3_STAT5A_STAT1_STAT5A_STAT5B_STAT5B) (modification, activates)
  

Text-mined interactions from Literome

O'Brien et al., J Biol Chem 1999 : STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130 utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone
Nagalakshmi et al., Int Immunopharmacol 2004 : Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells ... IL-22 induced the phosphorylation of STAT1 and STAT3 in Colo205, a colon epithelial cell line
Radaeva et al., Hepatology 2004 (Carcinoma, Hepatocellular...) : Stable overexpression of IL-22 in HepG2 cells constitutively activates STAT3 and induces expression of a variety of antiapoptotic ( e.g., Bcl-2, Bcl-xL, Mcl-1 ) and mitogenic ( e.g., c-myc, cyclin D1, Rb2, CDK4 ) proteins
Wolk et al., Immunity 2004 : In these cells, IL-22 activated STAT3 and directly and transcriptionally increased the expression of beta-Defensin 2 and beta-Defensin 3
Pan et al., Cell Mol Immunol 2004 (Drug-Induced Liver Injury) : Western blot analyses show that overexpression of IL-22 significantly enhances activation of STAT3 and expression of Bcl-xL, Bcl-2, and Mcl-1 proteins in liver injury induced by Con A
Weber et al., Infect Immun 2007 (Disease Models, Animal...) : IL-22BP-Fc completely blocked IL-22 induced STAT3 activation in hepatocytes in vitro
Bard et al., Leukemia 2008 (Lymphoma, Large-Cell, Anaplastic...) : Nucleophosmin (NPM)-ALK, the characteristic fusion gene oncoprotein expressed in ALK ( + ) ALCL, directly contributes to the aberrant expression of IL-22R1, as transfection of NPM-ALK in Jurkat cells induced IL-22R1 expression and IL-22 mediated STAT3 activation
Pickert et al., J Exp Med 2009 (Colitis...) : Studies in genetically engineered mice showed that epithelial STAT3 activation in dextran sodium sulfate colitis is dependent on interleukin (IL)-22 rather than IL-6 ... In summary, our data suggest that intestinal epithelial STAT3 activation regulates immune homeostasis in the gut by promoting IL-22 dependent mucosal wound healing
Neufert et al., Cell cycle (Georgetown, Tex.) 2010 (Colitis...) : Here, we extend our previous findings by showing epithelial STAT3 activation in human patients suffering from IBD and provide additional insights how the activation of epithelial STAT3 by IL-22 regulates intestinal homeostasis and mucosal wound healing
Yang et al., J Hepatol 2010 (Disease Models, Animal...) : The activation of STAT3 by rmIL-22 was reduced by the over-expression of a dominant negative IL-22R1
Park et al., Immunol Lett 2011 (Arthritis, Experimental...) : The presence of GSPE decreased the levels of IL-21, IL-22 , IL-26 and IL-17 production by human CD4 ( + ) T cells in a STAT3 dependent manner
Ozawa et al., Journal of ophthalmology 2011 : In innate chorioretinal inflammation, interleukin-6 family ligands induce STAT3 activation in photoreceptors, which causes UPS mediated excessive degradation of the visual substance, rhodopsin
Conrad et al., J Invest Dermatol 2012 (Psoriasis) : In this issue, Tohyama et al. identify a new link between type I IFNs and epidermal remodeling, by showing that type I IFNs specifically upregulate IL-22R expression on keratinocytes and, thereby, IL-22 mediated Stat3 phosphorylation in keratinocytes
Liu et al., Mol Cell Biochem 2012 : We show here that IL-22 activates Stat3 , p38 mitogen activated protein kinases ( MAPK ), and Akt pathways and inhibits Erk/MAPK pathway in naïve PC12 cells