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RHOA — STAT3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Debidda et al., J Biol Chem 2005
(Inflammation) :
We also found that although active
RhoA , Rac1, and Cdc42 could all
mediate Ser-727 and Tyr-705 phosphorylation and nuclear translocation of
STAT3 , the Rho GTPases were able to induce STAT3 activation independently of the interleukin-6 autocrine pathway, and active RhoA, Rac1, or Cdc42 could not form a stable complex with STAT3 as previously suggested, indicating an unappreciated mechanism of STAT3 activation by the Rho GTPases ... The
RhoA induced
STAT3 activation partly depended on Rho associated kinase (ROK) and involved multiple effector signals as revealed by the examination of effector domain mutants of RhoA ... Furthermore, loss of
STAT3 expression inhibited RhoA promoted cell proliferation and
blocked RhoA or ROK induced anchorage independent growth
Reipschläger et al., J Biol Chem 2012
:
We show that
RhoA activation
leads to phosphorylation and activation of
STAT3 and identify signal proteins involved in this pathway ...
RhoA dependent
STAT3 stimulation requires ROCK and Jun kinase activation as well as AP1 induced protein synthesis