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BCR — FCGR2B

Text-mined interactions from Literome

Wagle et al., J Immunol 1999 : Here we investigate the influence of the FcgammaRIIB1 on BCR mediated Ag processing and show that coligating the FcgammaRIIB1 and the BCR negatively regulates both BCR signaling for enhanced Ag processing and BCR mediated Ag internalization
Astoul et al., J Cell Biol 1999 : The FcgammaRIIB can thus antagonize BCR signals for PKB localization and prevent BCR stimulation of PKB activity which demonstrates the mechanism for the inhibitory action of the FcgammaRIIB on the BCR/PKB response
Brown et al., Cell Signal 2004 : FcgammaRIIb mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3'-inositol phosphatase, PTEN
Isnardi et al., Immunol Lett 2006 : We demonstrate that SHIP is necessary for human FcgammaRIIB to inhibit BCR signaling, and can not be replaced by SHP-1 or SHP-2
Sohn et al., J Immunol 2008 : That lipid rafts play a role in FcgammaRIIB 's regulation of BCR signaling was suggested by recent studies showing that a lupus associated loss of function mutation resulted in the receptor 's exclusion from lipid rafts and the failure to regulate BCR signaling
D'Ambrosio et al., Immunol Lett 1996 : These observations suggest that SHIP may play an important role in FcgammaRIIB1 dependent and independent regulation of BCR signaling
Wang et al., J Exp Med 1996 : Compared with control B cells, Lyn-/- B cells were hyper responsive to anti-IgM induced proliferation and defective in Fc gamma RIIB mediated suppression of B cell antigen receptor (BCR) signaling, indicating that Lyn is involved in the negative regulation of BCR signaling
Chan et al., Curr Biol 1998 : Tyrosine phosphorylation of Fc gamma RIIb1 in lyn-/- B cells was reduced but negative regulation of the BCR signal by Fc gamma RIIb1 was only modestly impaired
Sato et al., J Immunol 1998 (Lymphoma, B-Cell) : In Ag-specific Id-positive B cells, the co-cross linking of BCR and Fc gamma RIIB1 by anti-Id Ab resulted in the association of both Src homology 2-containing protein tyrosine phosphatase (SHP-1) and Src homology 2-containing inositol phosphatase ( SHIP ) with the Fc gamma RIIB1 ; however, only SHIP activity was detected
Liu et al., J Exp Med 1998 : These results demonstrate that Ship plays an essential role in FcgammaRIIB mediated inhibition of BCR signaling, and that Ship is a crucial negative regulator of Ca2+ flux and MAPK activation