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HSPB1 — RELA

Pathways - manually collected, often from reviews:

• KEGG Amoebiasis: HSPB1 → NFKB1/RELA (protein-protein, inhibition)

Text-mined interactions from Literome

Kammanadiminti et al., J Biol Chem 2006 (Colitis) : Gene silencing by small interfering RNA confirmed the role of Hsp27 in suppressing NF-kappaB activation at IkappaB kinase (IKK) level
Sur et al., J Invest Dermatol 2008 : Hsp27 regulates pro-inflammatory mediator release in keratinocytes by modulating NF-kappaB signaling ... Further studies showed that downregulation of Hsp27 resulted in induction of NF-kappaB reporter activity in keratinocytes
Voegeli et al., Appl Physiol Nutr Metab 2008 : The role of Hsp27 and Hsp70 in NF-kappaB activation is reviewed here, along with evidence suggesting that HSPs regulate Ang II-induced blood pressure through the regulation of NF-kappaB
Bao et al., Mol Pharmacol 2009 : Correspondingly, the elevated HSP27 and HSP70 suppressed inhibitor kappaB degradation and nuclear factor kappaB (NF-kappaB) activation that were caused by ConA
Guo et al., BMC cancer 2009 (Carcinoma, Hepatocellular...) : Altogether, these findings revealed a possible effect of HSP27 on apoptosis in metastatic HCC cells, in which HSP27 may regulate NF-kB pathway activation
Dodd et al., FASEB J 2009 (Atrophy) : Hsp27 inhibits IKKbeta induced NF-kappaB activity and skeletal muscle atrophy ... Previous work, in nonmuscle cells, has shown that Hsp27 inhibits TNF-alpha induced NF-kappaB activation ... During skeletal muscle disuse, Hsp25/27 levels are decreased and NF-kappaB activity increased , and this increase in NF-kappaB activity is required for disuse muscle atrophy
Liu et al., Cell Immunol 2010 (Inflammation) : Further studies have shown that HSP27 regulated LPS induced activation of NF-kappaB by interacting with TRAF6 and increasing the association of TRAF6-IKKgamma