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IFI27 — RHOA
Text-mined interactions from Literome
Seasholtz et al., Circ Res 2001
(Hypertension) :
Wortmannin ( 10 nmol/L ) fully inhibited the decrease in
p27 ( Kip1 )
induced by
RhoA , and a membrane targeted catalytic subunit of phosphatidylinositol-3 kinase ( PI3K [ p110 ( CAAX ) ] ) decreased p27 ( Kip1 ) expression, suggesting that RhoA signals through PI3K
Wu et al., Cancer Res 2006
(Breast Neoplasms...) :
Expression of
p27deltaNLS in MCF7 breast cancer cells
down-regulated RhoA and increased motility, survival, and Akt levels without an effect on cell cycle distribution
Larrea et al., Proc Natl Acad Sci U S A 2009
(MAP Kinase Signaling System) :
We present evidence that RSK1 drives
p27 phosphorylation at T198 to
increase RhoA-p27 binding and cell motility ... Thus T198 phosphorylation not only stabilizes p27 and mislocalizes p27 to the cytoplasm but also promotes
RhoA-p27 interaction and
RhoA pathway
inhibition
Larrea et al., Cell cycle (Georgetown, Tex.) 2009
(Neoplasms) :
Further characterization of post-translational modifications governing
p27 localization and its
action on
RhoA and the actin cytoskeleton may provide critical insights into human cancer metastasis
Lee et al., Frontiers in bioscience (Landmark edition) 2011
(Neoplasm Invasiveness...) :
TM4SF5 induces epithelial-mesenchymal transition (EMT) by morphological changes resulting from inactivation of
RhoA mediated by stabilized cytosolic
p27kip1
Konecny et al., Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 2010
:
After transport in cytoplasm,
p27 Kip1 binds to RhoA thus
prevent activation of
RhoA by GEFs, thus inhibit GDP-GTP exchange mediated by GEFs
Wei et al., Cell Signal 2013
(Stomach Neoplasms) :
The depletion of
p27 increased
RhoA ( Ras homolog family member A ) activity, upregulated RECK, and downregulated E-cadherin and Sp1 in STAT3 depleted cells
Ruiz-OntaƱon et al., Stem Cells 2013
:
Of note,
p27 is upregulated in TM cells and
inhibits RhoA activity
Weber et al., J Biol Chem 1997
:
C3 transferase also inhibited PDGF induced p27 ( KIP1 ) degradation, thus further implicating
RhoA in
p27 ( KIP1 )
regulation
Hu et al., J Biol Chem 1999
:
RhoA stimulates
p27 ( Kip ) degradation through its regulation of cyclin E/CDK2 activity ... In the absence of serum, expression of constitutively active
RhoA ( 63 )
resulted in significant stimulation of cyclin E/CDK2 activity and degradation of
p27 ( Kip ) ... In addition, expression of dominant negative
RhoA blocked serum induced cyclin E/CDK2 activity and
p27 ( Kip ) degradation ... Taken together, these data show that
RhoA regulates
p27 ( Kip ) degradation through its regulation of cyclin E/CDK2 activity