Gene interactions and pathways from curated databases and text-mining

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CCND1 — STAT5B

Pathways - manually collected, often from reviews:

  • KEGG Jak-STAT signaling pathway: STAT1/STAT2/STAT3/STAT4/STAT5A/STAT5B/STAT6 → CCND1/CCND2/CCND3 (gene expression, expression)

Text-mined interactions from Literome

Joung et al., Exp Mol Med 2005 (Breast Neoplasms) : These data suggest that STAT5b may mediate the transcriptional activation of cyclin D1 after hypoxic stimulation
Lim et al., Int J Oncol 2010 (Anoxia...) : We confirmed that STAT5b, cyclin D1 , and IGF-1R is up-regulated by hypoxia, and the increased STAT5b binds strongly to the STAT5 binding sites contained within the distal 5'-flanking region of IGF-1 gene in breast cancer cells