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IL3 — STAT5B
Pathways - manually collected, often from reviews:
-
BioCarta il 3 signaling pathway:
IL-3/IL-3R-alpha/IL-3R-beta/JAK2 complex (JAK2-CSF2RB-IL3RA-IL3)
→
STAT5 (STAT5A/STAT5B)
(modification, activates)
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
→
STAT5 (STAT5A/STAT5B)
(modification, activates)
Azam et al., EMBO J 1995, Chin et al., Blood 1996
Evidence: assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
→
STAT5-active (STAT5A/STAT5B)
(modification, activates)
Azam et al., EMBO J 1995, Chin et al., Blood 1996
Evidence: assay, physical interaction
-
Reactome Reaction:
IL3
→
STAT5B
(reaction)
Behrmann et al., J Biol Chem 1997, Flores-Morales et al., Mol Cell Endocrinol 1998
-
Reactome Reaction:
IL3
→
STAT5B
(indirect_complex)
Text-mined interactions from Literome
Cohney et al., Mol Cell Biol 1999
:
Additionally, in lymphocytes expressing SOCS-3 but not CIS, IL-2 induced tyrosine phosphorylation of STAT5b was markedly reduced, while there was only a weak effect on
IL-3 mediated
STAT5b tyrosine phosphorylation
Natarajan et al., Glia 2004
(Encephalitis...) :
In this study, we found that in vitro treatment of EOC-20 microglial cells with tyrphostin AG490 blocked
IL-3 induced tyrosine phosphorylation of JAK2, STAT5A, and
STAT5B signaling proteins ... Stable transfection of EOC-20 cells with a dominant negative JAK2 mutant also blocked
IL-3 induced tyrosine phosphorylation of JAK2, STAT5A, and
STAT5B in microglia