Joly et al., Mol Immunol 2005
:
An inhibitor of JAK2 kinase ( Janus kinase ), down-regulated IFN-gamma induced HBD-1 and HBD-3 expression, suggesting a role for the JAK/signal transducer and activator of transcription ( STAT ) signaling pathway in their expression
Albanesi et al., J Immunol 2007
:
We demonstrate here that stimulation of keratinocytes with TNF-alpha/IFN-gamma induces HBD-2 and HBD-3 by activating STAT-1 and NF-kappaB signaling ... This interferes with STAT-1 and NF-kappaB signaling, thereby inhibiting TNF-alpha/IFN-gamma mediated induction of HBD-2 and HBD-3