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IFNG — PLCG2
Text-mined interactions from Literome
Chang et al., J Biol Chem 2002
:
Thus, in NCI-H292 epithelial cells,
IFN-gamma activates
PLC-gamma2 via an upstream tyrosine kinase to induce activation of PKC-alpha and c-Src or Lyn, resulting in activation of STAT1alpha, and GAS in the ICAM-1 promoter, followed by initiation of ICAM-1 expression and monocyte adhesion
Tassi et al., J Immunol 2005
(Herpesviridae Infections) :
Why
PLCgamma2 is more important than PLCgamma1 for NK cell activation and whether PLCgamma2 is also
critical for NK cell development, secretion of
IFN-gamma , and clearance of viral infections in vivo is not known