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NTRK2 — PLCG2

Pathways - manually collected, often from reviews:

• KEGG Neurotrophin signaling pathway: NTRK2 → PLCG1/PLCG2 (protein-protein, activation)

Text-mined interactions from Literome

Goggi et al., Brain Res 2003 : Three proteins mediating signalling pathways are activated by the binding of BDNF to TrkB : phosphoinositol-3 kinase (PI3K) ; Ras-MEK and phospholipase C-gamma ( PLCgamma )
Ginés et al., J Biol Chem 2010 (Huntington Disease...) : Here, we demonstrate reduced TrkB mediated Ras/MAPK/ERK1/2 signaling but unchanged phosphatidylinositol 3-kinase/Akt and phospholipase Cgamma activation in knock-in HD striatal cells
He et al., J Neurosci 2010 (Disease Models, Animal...) : Disruption of TrkB mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis