◀ Back to IFNG

IFNG — RB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RB1 → IFNG (decreases)
  Evidence: IFNG inhibited EGF induced Rb hyperphosphorylation.
• OpenBEL Selventa BEL large corpus: RB1 → IFNG (decreases) Amrani et al., Am J Physiol Lung Cell Mol Physiol 2003*
  Evidence: In addition, IFN-gamma decreased activation of cdk2 and expression of cyclin E, upstream signaling molecules responsible for Rb hyperphosphorylation in the late G1 phase.
• OpenBEL Selventa BEL large corpus: RB1 → IFNG (decreases)
  Evidence: p53 and p21 protein levels were increased and pRb protein level was decreased in IFN-g-treated cells.

Text-mined interactions from Literome

Zhu et al., Oncogene 1999 : pRB is required for interferon-gamma-induction of the MHC class II abeta gene ... pRB is required for IFN-gamma-induction of MHC class II in human tumor cell lines, providing a potential link between tumor suppressors and the immune system
Musikacharoen et al., Blood 2005 : Promoter analyses in a mouse macrophage cell line, RAW264.7, revealed that the 2508-bp region upstream of the transcriptional start site is sufficient for the full transcriptional activation of the IL12RB1 gene by IFN-gamma or IL-15 ... Consistently, IL-15, as a histone deacetylase inhibitor, synergistically enhanced IL12RB1 gene expression and promoter activation by IFN-gamma through increased protein binding to ETS/PU.1 and IRE/ISRE sites ... Additionally, IL12RB1 promoter activation by IFN-gamma was enhanced by the coexpression of a coactivator protein, CBP