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IL6ST — STAT1

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL27-mediated signaling events: STAT1 (STAT1) → IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3) (modification, collaborate)
  Lucas et al., Proc Natl Acad Sci U S A 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT1 (STAT1) (modification, activates) Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Gerhartz et al., J Biol Chem 1996
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL27-mediated signaling events: STAT1 (STAT1) → IL27/IL27R/JAK1 complex (IL27-EBI3-IL27RA-IL6ST-JAK1) (modification, collaborate)
  Takeda et al., J Immunol 2003
  Evidence: physical interaction, other species
• NCI Pathway Database IL27-mediated signaling events: IL27/IL27R/JAK1 complex (IL27-EBI3-IL27RA-IL6ST-JAK1) → STAT1 (dimer) complex (STAT1) (modification, activates)
  Takeda et al., J Immunol 2003
  Evidence: physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT1 (STAT1) (modification, activates) Liu et al., Proc Natl Acad Sci U S A 1998
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT1/PIAS1 complex (STAT1-PIAS1) (modification, activates)
  Liu et al., Proc Natl Acad Sci U S A 1998
  Evidence: physical interaction
• Reactome Reaction: STAT1 → IL6ST (reaction) Zhong et al., Science 1994, Gerhartz et al., J Biol Chem 1996, Hemmann et al., J Biol Chem 1996
• Reactome Reaction: STAT1 → IL6ST (indirect_complex) Decker et al., Oncogene 2000*, Gerhartz et al., J Biol Chem 1996, Hemmann et al., J Biol Chem 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: IL6ST — STAT1 (association, inferred by author) Hemmann et al., J Biol Chem 1996
• IRef Intact Interaction: IL6ST — STAT1 (association, competition binding) Gerhartz et al., J Biol Chem 1996
• IRef Intact Interaction: IL6ST — STAT1 (association, electrophoretic mobility shift assay) Gerhartz et al., J Biol Chem 1996

Text-mined interactions from Literome

Jenkins et al., Exp Hematol 2002 (Thrombocytopenia) : This study examined the specific contribution of gp130 mediated STAT1/3 signaling to the regulation of hematopoiesis ... Collectively, these results reveal that gp130 mediated STAT1/3 activation is required to maintain the normal balance of hematopoietic progenitors during fetal and adult hematopoiesis ... Furthermore, they suggest two distinct roles for gp130 mediated STAT1/3 activation in hematopoiesis, one restricting the production of immature hematopoietic progenitor cells and the other promoting the functional maturation of megakaryocytes to produce platelets
Sanz et al., Glia 2008 : The binding of IL-6 to its receptor (IL6R) triggers gp130 mediated activation of STAT1 and STAT3 as well as SHP2 phosphatase and ERK1/2
Lai et al., J Biol Chem 1995 : However, gp130 preferentially activated STAT1 and STAT3