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BMP2 — MSX2

Text-mined interactions from Literome

Chen et al., Proc Natl Acad Sci U S A 2000 : In chick mandibles, exogenous bone morphogenetic protein ( BMP ) induces Msx expression and together with fibroblast growth factor promotes the development of Sonic hedgehog expressing epithelial structures
Daluiski et al., Nat Genet 2001 : Here we show that BMP3 is an antagonist of osteogenic BMPs : BMP3 dorsalizes Xenopus laevis embryos, inhibits BMP2 mediated induction of Msx2 and blocks BMP2 mediated differentiation of osteoprogenitor cells into osteoblasts ... Here we show that BMP3 is an antagonist of osteogenic BMPs : BMP3 dorsalizes Xenopus laevis embryos, inhibits BMP2 mediated induction of Msx2 and blocks BMP2 mediated differentiation of osteoprogenitor cells into osteoblasts
Rice et al., Dev Biol 2003 (Hydrocephalus) : We have previously shown that BMP induces Msx2 in calvarial mesenchyme ( Development 125, 1241-1251, 1998 ) ... We also show that BMP induced expression of Msx2 and Alx4 requires Foxc1
Hussein et al., J Biol Chem 2003 : Here we show in murine embryonic stem cells that BMP dependent activation of Msx2 is mediated via the cooperative binding of Smad4 at two Smad binding elements and of lymphoid enhancing factor ( Lef1 ) at two Lef1/TCF binding sites
Laurikkala et al., Dev Biol 2003 : Recombinant ectodin protein antagonized the BMP mediated induction of Msx2 expression in cultured tooth explants, indicating that ectodin is a secreted BMP inhibitor
Tribulo et al., Development 2003 : All the results show that a reduction in the level of Bmp activity leads to an increase in the expression of Msx genes in the neural plate border
Osyczka et al., Cells Tissues Organs 2004 : Overexpression of Msx-2 in human and rat MSC, however, did not alter alkaline phosphatase levels, which suggests that absence of BMP stimulated alkaline phosphatase was not caused by the BMP-2 induced increase in Msx-2
van Bezooijen et al., J Exp Med 2004 (Bone Diseases, Developmental...) : In addition, sclerostin had no effect on BMP stimulated Smad phosphorylation and direct transcriptional activation of MSX-2 and BMP response element reporter constructs in KS483 cells
Ichida et al., J Biol Chem 2004 : Interestingly the expression of Msx2 was induced by bone morphogenetic protein 2 treatment in Runx2-deficient mesenchymal cells
Liu et al., Dev Biol 2005 : Furthermore, our data uncovered different Bmp4 thresholds for expression of the Bmp dependent Msx1 and Msx2 genes in mandibular mesenchyme
Amano et al., J Biol Chem 2008 : These data suggest that Msx2 requires BMP2/Smad signaling for its chondrogenic action
Koide et al., Biochim Biophys Acta 2009 (Embryo Loss) : In addition, BMP4 induces more Msx2 in the absence of fortilin than in its presence
Sun et al., Development 2013 : We propose that Foxc1 sets a threshold for the Bmp dependent activation of Msx2 , thus controlling the differentiation of osteogenic precursor cells and the rate and pattern of calvarial bone development
Chen et al., J Exp Zool 1998 : BMPs may in some cases trigger the cell death cascade, while Msx gene products regulate Bmp expression