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EGF — FOXO3

Text-mined interactions from Literome

Li et al., Biochem Pharmacol 2010 : Simultaneously, they suppressed EGF induced decreases of FOXO3a nucleus accumulation and p27 ( Kip1 ) mRNA expression
Qi et al., BMC cancer 2011 (Colonic Neoplasms) : Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity ... The aim of this study was to assess if genistein exerts anti-proliferative properties by attenuating the negative effect of EGF on FOXO3 activity ... The effect of genistein on proliferation stimulated by EGF mediated loss of FOXO3 was examined in human colonic cancer HT-29 cells ... EGF induced FOXO3 phosphorylation and translocation were assessed in the presence of genistein ... EGF mediated loss of FOXO3 interactions with p53 ( co-immunoprecipitation ) and promoter of p27kip1 ( ChIP assay ) were examined in presence of genistein in cells with mutated p53 ( HT-29 ) and wild type p53 ( HCT116 ) ... Upstream of FOXO3, genistein acts via the PI3K/Akt pathway to inhibit EGF stimulated FOXO3 phosphorylation ( i.e. favors active state )
Saxena et al., Antioxid Redox Signal 2013 (Colonic Neoplasms...) : Inhibition of AR also prevented the epidermal growth factor induced phosphorylation of phosphatidylinositol 3-kinase (PI3K), serine/threonine kinase ( AKT ), c-Jun, c-Fos, PTEN, and FOXO3a , and deoxyribonucleic acid ( DNA ) -binding activity of AP-1