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LEP — RETN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RETN → LEP (decreases) Kougias et al., J Surg Res 2005*
  Evidence: Resistin appears to be an important regulator of glucose homeostasis, adipogenesis, and, potentially, inflammation [65, 66]. Obesity induced by a high fat diet, mutation of the leptin gene (ob-/ob- mice), or the leptin receptor gene (db-/db- mice) is associated with increased circulating resistin concentrations [50]. Resistin induces insulin resistance in mice and regulates the deposition of adipose tissue through a negative feedback mechanism.

Text-mined interactions from Literome

Chen et al., Metabolism 2003 (Body Weight...) : Adipose leptin and hypothalamic Ob-R mRNA were not different from controls, but resistin was increased ( P < .05 ), and muscle GLUT4 content was decreased ( P < .05 ) in ETOH offspring compared with controls
Asensio et al., Endocrinology 2004 (Diabetes Mellitus...) : The lack of effect of leptin on resistin in db/db mice indicated that the leptin inhibitory action on resistin expression requires the long leptin receptor isoform ... In addition, we demonstrated that the effect of leptin on resistin expression was centrally mediated
Asensio et al., Int J Obes Relat Metab Disord 2004 (Insulin Resistance) : We observed increased adipose tissue resistin expression in the early phase of high-fat diet induced obesity as well as decreased resistin expression in response to leptin
Johnston et al., Br J Dermatol 2008 (Chronic Disease...) : In vitro, both leptin and resistin could induce CXCL8 and tumour necrosis factor-alpha production by blood monocytes, and leptin could additionally induce IL-1beta and IL-1 receptor antagonist production
Howell et al., Toxicol In Vitro 2011 : Exposure to DDE significantly increased the release of leptin , resistin, and adiponectin from mature adipocytes with corresponding increases in expression of resistin and adiponectin
Sălăgeanu et al., J Med Life 2010 (Colonic Neoplasms...) : Taken together, these results of this study suggest that adipokines, in particular resistin and leptin may be involved in development and progression of colon cancer