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CASP3 — PPARA
Text-mined interactions from Literome
Billiet et al., J Mol Biol 2008
:
Finally,
PPARalpha activation
reduced the lidocaine induced
caspase-3 activity and apoptosis, which might be due to the VDUP-1 mediated regulation of the Bax/Bcl-2 ratio
Chen et al., American journal of physiology. Renal physiology 2009
(Reperfusion Injury) :
Overexpression of prostacyclin using an adenovirus could also
induce PPAR-alpha translocation from the cytosol into the nucleus to inhibit
caspase-3 activation
He et al., Zhongguo Fei Ai Za Zhi 2006
:
Activated
PPAR-? can
increase caspase-3 activity to induce apoptosis of cells
Wang et al., Acta Diabetol 2013
:
Additionally, the enhancement of
PPAR? expression by treatment with TZDs
inhibited the expression of
caspase 3 in IL-1ß/IFN-? induced NIT-cells
Wang et al., Oncogene 2012
(Colorectal Neoplasms) :
More importantly, the opposing effects of PPARd and
PPAR? in regulating programmed cell death are
mediated by survivin and
caspase-3
Yuan et al., Cancer prevention research (Philadelphia, Pa.) 2012
(Genetic Predisposition to Disease) :
Here, we report that the absence of
Sca-1 in the mammary gland
resulted in higher levels of
PPAR? and PTEN, and a reduction of pSer84PPAR?, pERK1/2, and PPARd ... Reduction of
Sca-1 expression in mammary tumor cells by RNA interference
resulted in a phenotype similar to the Sca-1 deficient mammary gland, as evidenced by increased
PPAR? expression and transcriptional activity, resulting in part from a lesser susceptibility to proteasomal degradation
Qiu et al., Food Chem Toxicol 2013
(MAP Kinase Signaling System...) :
Caspase-3 was also activated and
PPAR-? protein expression
increased in drug induced apoptosis