Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of F2-ITGAV-ITGB3
→
VEGFA
(increases)
Evidence: Our results show that VEGF can induce activation of the key integrins involved in angiogenesis, thereby establishing a mechanism by which the VEGF/VEGFR system can regulate cellular adhesive and migratory responses. Prothrombin, recently identified as an activation- dependent ligand of aVb3 (Byzova and Plow, 1998), supported limited adhesion of nonstimulated HUVECs; however, when these cells were stimulated with as little as 10 ng/ml VEGF165, adhesion to prothrombin increased by more than 10-fol...
OpenBEL Selventa BEL large corpus:
Complex of F2-ITGAV-ITGB3
→
Complex of ITGAV-ITGB3
(directlyIncreases, F2/ITGAV/ITGB3 Activity)
Evidence: Our results show that VEGF can induce activation of the key integrins involved in angiogenesis, thereby establishing a mechanism by which the VEGF/VEGFR system can regulate cellular adhesive and migratory responses. Prothrombin, recently identified as an activation- dependent ligand of aVb3 (Byzova and Plow, 1998), supported limited adhesion of nonstimulated HUVECs; however, when these cells were stimulated with as little as 10 ng/ml VEGF165, adhesion to prothrombin increased by more than 10-fol...