◀ Back to IL12B
IL12B — RNF19A
Text-mined interactions from Literome
Zhang et al., J Immunol 2000
:
In this report we demonstrate that
IL-12 activates mitogen activated protein kinase kinase 3/6 ( MKK ) and
p38 mitogen activated protein kinase ( MAPK ), but not p44/42 ( ERK ) or stress activated protein kinase/c-Jun N-terminal kinase MAPK
Mavropoulos et al., Blood 2005
:
Mitogen activated protein kinase
p38 was
activated strongly by IL-18 and weakly by
IL-12 in natural killer cells but was not activated by either cytokine in T cells
Kitanaka et al., Biochem Biophys Res Commun 2006
:
Collectively, it is suggested that E-FABP may be a novel negative regulator of IL-12 production in DCs, and this regulation may be exerted via its involvement in the
p38MAPK mediated transcription of
IL-12p35
Dobreva et al., Cytokine 2008
(MAP Kinase Signaling System) :
The inhibition of both JNK and
p38 augmented
IL-12p40 production
Mitchell et al., J Infect Dis 2010
:
IL-12p40 was significantly
inhibited by both
p38 mitogen activated protein kinase ( MAPK ) and extracellular signal regulated kinase inhibitors, whereas IL-12p70 was inhibited by p38 MAPK inhibitor alone
Rastogi et al., Am J Respir Crit Care Med 2011
(Sarcoidosis, Pulmonary) :
Inhibition of
p38 , but not ERK,
attenuated production of both
IL12/IL23p40 and TNF-a ... Inhibition of
p38 , but not ERK,
attenuated production of both
IL12/IL23p40 and TNF-a
Yang et al., J Immunol 2010
(Leishmaniasis) :
We show that inhibition of
p38 dramatically
increased IL-12 production upon stimulation, while decreasing TNF-a
Katholnig et al., J Immunol 2013
:
p38a signaling in myeloid immune cells promoted IL-10 but
inhibited IL-12 expression via mTOR and blocked the differentiation of proinflammatory CD4 ( + ) Th1 cells