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GGA2 — HSP90AA1

Text-mined interactions from Literome

Katsuno et al., Proc Natl Acad Sci U S A 2005 (Motor Neuron Disease) : In a cell model of SBMA, GGA increased the levels of Hsp70, Hsp90 , and Hsp105 and inhibited cell death and the accumulation of pathogenic AR. Oral administration of GGA also up-regulated the expression of HSPs in the central nervous system of SBMA-transgenic mice and suppressed nuclear accumulation of the pathogenic AR protein, resulting in amelioration of polyglutamine dependent neuromuscular phenotypes
Liu et al., Zhongguo Fei Ai Za Zhi 2011 (Lung Neoplasms) : The aim of this study is to investigate the relationship between the GGA induced overexpression of Hsp90 and chemoresistance to Cisplatin in SPCA-1 and H446 cell line ... The protein expressions of Hsp90 induced by GGA at different concentrations were analyzed by Immunofluorescence and Western blotting
Fujimura et al., Arterioscler Thromb Vasc Biol 2012 (MAP Kinase Signaling System) : Geranylgeranylacetone ( GGA ) induces expression of heat shock protein 90 (Hsp90) , an adaptor molecule for assembly of endothelial nitric oxide synthase (eNOS) phosphorylation complex ... The purpose of this study was to determine whether GGA enhances Hsp90 expression and augments endothelium dependent vasodilation via upregulation of eNOS in humans ... GGA increased Hsp90 expression and phosphorylation of eNOS and AMPK but not Akt in HUVECs and increased Hsp90 expression in peripheral blood mononuclear cells ... These findings suggest that GGA induced activation of Hsp90/AMPK significantly increased NO-mediated vasodilation in healthy subjects, as well as in smokers