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DAXX — PML

Pathways - manually collected, often from reviews:

• BioCarta regulation of transcriptional activity by pml: DAXX → PML/sp100/DAXX complex (PML-SP100-DAXX) (modification, collaborate)
  
• BioCarta regulation of transcriptional activity by pml: DAXX → PML/sp100 complex (PML-SP100) (modification, collaborate)
  
• BioCarta regulation of transcriptional activity by pml: PML/sp100/DAXX complex (PML-SP100-DAXX) → PML/sp100 complex (PML-SP100) (modification, collaborate)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: PML — DAXX Li et al., Mol Cell Biol 2000*
• IRef Bind_translation Interaction: PML — DAXX (unspecified method) Li et al., Mol Cell Biol 2000*
• IRef Biogrid Interaction: PML — DAXX (physical association, affinity chromatography technology) Meinecke et al., Proc Natl Acad Sci U S A 2007*
• IRef Biogrid Interaction: PML — DAXX (direct interaction, two hybrid) Lehembre et al., Oncogene 2001*
• IRef Biogrid Interaction: PML — DAXX (physical association, affinity chromatography technology) Zhong et al., J Exp Med 2000*
• IRef Biogrid Interaction: PML — DAXX (colocalization, imaging technique) Cuchet-Lourenço et al., PLoS Pathog 2011*
• IRef Biogrid Interaction: PML — DAXX (direct interaction, enzymatic study) Chu et al., Oncogene 2011*
• IRef Biogrid Interaction: PML — DAXX (physical association, affinity chromatography technology) Jang et al., Biochem Biophys Res Commun 2002*
• IRef Biogrid Interaction: PML — DAXX (physical association, affinity chromatography technology) Chang et al., Mol Cell 2011*
• IRef Biogrid Interaction: PML — DAXX (physical association, affinity chromatography technology) Wethkamp et al., J Biol Chem 2011*
• IRef Biogrid Interaction: PML — DAXX (colocalization, biochemical) Ferguson et al., J Proteome Res 2007*
• IRef Biogrid Interaction: PML — DAXX (direct interaction, two hybrid) Ishov et al., J Cell Biol 1999*
• IRef Biogrid Interaction: PML — DAXX (direct interaction, two hybrid) Li et al., Mol Cell Biol 2000*
• IRef Biogrid Interaction: PML — DAXX (physical association, affinity chromatography technology) Li et al., Mol Cell Biol 2000*
• IRef Biogrid Interaction: PML — DAXX (colocalization, imaging technique) Li et al., Mol Cell Biol 2000*
• IRef Hprd Interaction: PML — DAXX (in vitro) Ishov et al., J Cell Biol 1999*, Li et al., Mol Cell Biol 2000*, Zhong et al., J Exp Med 2000*, Lin et al., J Biol Chem 2003*, Mizuta et al., Cell Biol Int 2004*
• IRef Hprd Interaction: PML — DAXX (in vivo) Ishov et al., J Cell Biol 1999*, Li et al., Mol Cell Biol 2000*, Zhong et al., J Exp Med 2000*, Lin et al., J Biol Chem 2003*, Mizuta et al., Cell Biol Int 2004*
• IRef Hprd Interaction: PML — DAXX (two hybrid) Ishov et al., J Cell Biol 1999*, Li et al., Mol Cell Biol 2000*, Zhong et al., J Exp Med 2000*, Lin et al., J Biol Chem 2003*, Mizuta et al., Cell Biol Int 2004*
• IRef Intact Interaction: Complex of HDAC1-DAXX-PML (association, anti bait coimmunoprecipitation) Ecsedy et al., Mol Cell Biol 2003*
• IRef Intact Interaction: PML — DAXX (colocalization, imaging technique) Li et al., Mol Cell Biol 2000*
• IRef Intact Interaction: PML — DAXX (physical association, coimmunoprecipitation) Li et al., Mol Cell Biol 2000*
• IRef Intact Interaction: PML — DAXX (physical association, two hybrid) Li et al., Mol Cell Biol 2000*
• IRef Intact Interaction: PML — DAXX (colocalization, fluorescence microscopy) Chen et al., Mol Cell Biol 2003*
• IRef Intact Interaction: PML — DAXX (physical association, anti bait coimmunoprecipitation) Yuan et al., Cancer Cell 2011
• IRef Mppi Interaction: PML — DAXX (coimmunoprecipitation) Li et al., Mol Cell Biol 2000*
• IRef Mppi Interaction: PML — DAXX (two hybrid) Li et al., Mol Cell Biol 2000*
• IRef Ophid Interaction: PML — DAXX (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Li et al., Mol Cell Biol 2000 (Leukemia, Promyelocytic, Acute) : In addition, SUMO-1 modification of PML is required for sequestration of Daxx to the PODs and for efficient inhibition of Daxx mediated transcriptional repression
Santiago et al., Cell cycle (Georgetown, Tex.) 2009 : Furthermore, wt Daxx also strongly colocalizes with PMLDeltaS mutant, in which all three sumoylation sites are mutated, whereas PMLDeltaS only weakly colocalizes with Daxx I7/733K mutant, suggesting that SIM-SUMO interaction is not essential for but enhances PML-Daxx interaction