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ANXA6 — PRL

Text-mined interactions from Literome

Bishop et al., J Endocrinol 2006 (Lymphoma) : Prolactin activates mammalian target-of-rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 in lymphoma cells ... This study showed that PRL stimulated the phosphorylation of mTOR, p70S6K , Akt, and Jak2 kinases in a dose- and time dependent manner in PRL dependent rat Nb2 lymphoma cells ... PRL induced phosphorylation of p70S6K and 4E-BP1 was inhibited by rapamycin, but not by okadaic acid ( inhibitor of protein phosphatase, PP2A ) ... PRL induced a transient interaction between p70S6K and the catalytic subunit of PP2A ( PP2Ac ) in 1 and 2 h, whereas a PP2Ac-4E-BP1 complex was constitutively present in quiescent and PRL treated Nb2 cells
Wu et al., J Cell Biochem 2008 : Lastly, we show that prolactin induced tyrosine phosphorylation of Jak2 and Stat5 as well as serine/threonine phosphorylation of p70S6K and S6 ribosomal protein are downregulated by TGF-beta, although the former event requires considerably long exposure to TGF-beta
Sidis et al., Endocrinology 1994 : Prolactin induces rapid p95/p70 tyrosine phosphorylation, and protein binding to GAS-like sites in the anx Icp35 and c-fos genes