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BMP2 — CREB5
Text-mined interactions from Literome
Zhang et al., PloS one 2011
:
Importantly, we found that the PTH-CREB signaling pathway functioned as an effective activator of BMP2 expression, as pharmacologic and genetic modulation of
PTH-CREB activity significantly
affected BMP2 expression levels in these cells
Lee et al., J Cell Physiol 1997
:
We showed the following points : 1 ) in micromass cultures, activation of PKA enhances chondrogenesis and increases the phosphorylation of CREB; 2 )
BMP-2 , a chondrogenic stimulator,
increases PKA activity and the level of phosphorylated CREB ( P-CREB ) ; 3 ) H8, a PKA inhibitor, inhibits chondrogenesis ; 4 ) the chondrogenic activities of BMP-2 and cAMP are suppressed by H8 ; and 5 ) long-term TPA treatment ( a protein kinase C ( PKC ) modulator ) inhibits chondrogenesis and decreases the levels of
CREB and P-CREB