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NOS3 — SIM2

Text-mined interactions from Literome

Li et al., Acta Pharmacol Sin 2012 (Myocardial Infarction...) : SIM significantly increased the activities of PKA and constitutive NOS , and increased Ser ( 133 ) p-CREB protein, Ser ( 1179 ) p-eNOS, and Ser ( 635 ) p-eNOS in ischemic myocardium ... Intravenous infusion of the PKA inhibitor H-89 ( 1 µg·kg ( -1 ) ·min ( -1 ) ) partially abrogated the SIM induced cardioprotection and eNOS phosphorylation ... In contrast, intravenous infusion of the eNOS inhibitor L-NNA ( 10 mg·kg ( -1 ) ) completely abrogated the SIM induced cardioprotection and eNOS phosphorylation during ischemia and reperfusion, but did not affect the activity of PKA
Kaesemeyer et al., J Am Coll Cardiol 1999 : Both PRA and SIM activate eNOS , but SIM is much less effective