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AHR — IL5
Text-mined interactions from Literome
Mould et al., J Immunol 2000
(Bronchial Hyperreactivity...) :
Gene transfer of
IL-5 and/or eotaxin to the lungs of naive mice induced a pronounced and selective airways eosinophilia, but did not
result in eosinophil degranulation or
AHR
Matsumoto et al., Int Arch Allergy Immunol 2003
(Eosinophilia...) :
Genetically IL-5-deficient mice lack antigen induced airway eosinophilia, but little is known about the
role of
IL-5 in accumulation and activation of CD4+ T cells in the lung and in
airway hyperresponsiveness (AHR) ... We examined the
role of
IL-5 in CD4+ T cell activation, cytokine production, and
AHR upon Asc sensitization
Yang et al., J Allergy Clin Immunol 2003
(Bronchial Hyperreactivity...) :
Eotaxin-2 and
IL-5 cooperatively
promoted eosinophil accumulation, IL-13 production, and
AHR to methacholine
Webb et al., Eur J Immunol 2003
(Bronchial Hyperreactivity...) :
IL-4Ralpha/IL-5 ( -/- ) mice were significantly defective in their ability to produce IL-13 and failed to develop AHR, suggesting that
IL-5 indirectly
regulates AHR in allergic IL-4Ralpha ( -/- ) mice by an IL-13 dependent mechanism
Hall et al., Infect Immun 1998
(Asthma...) :
Taken together, these data indicate that
IL-5 and eosinophils are
required for the induction of
AHR by filarial helminths