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ABCB1 — NFKB1

Text-mined interactions from Literome

Ogretmen et al., Biochemistry 1999 (Breast Neoplasms) : Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region
Ros et al., Hepatology 2001 (Carcinoma, Hepatocellular...) : Induction of Mdr1b expression by tumor necrosis factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signaling ... We show a critical role for NF-kappaB in activation of Mdr1b gene expression both in primary rat hepatocytes and in rat hepatoma H-4-II-E cells ... In conclusion our results show that activation of the rat Mdr1b gene by TNF-alpha is a result of NF-kappaB signaling and independent of p53