◀ Back to EPHB2

EPHB2 — ERBB2IP

Text-mined interactions from Literome

Rangwala et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Reducing erbin expression using a targeted siRNA in primary cultures of Schwann cells results in altered cell-cell interactions, disruption of E-cadherin adherens junctions, increased cell proliferation, and elevated levels of phosphorylated ERK , all phenotypes observed in cells that lack merlin
Harmon et al., J Clin Invest 2013 (Keratoderma, Palmoplantar...) : Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation ... The screen revealed that Erbin ( also known as ERBB2IP ), a known ERK regulator , binds DSG1 ... Furthermore, ERK inhibition and the induction of differentiation markers by DSG1 required both Erbin and DSG1 domains that participate in binding Erbin ... Erbin blocks ERK signaling by interacting with and disrupting Ras-Raf scaffolds mediated by SHOC2, a protein genetically linked to the RASopathy, Noonan-like syndrome with loose anagen hair ( NS/LAH )
Liu et al., Mol Immunol 2013 (Breast Neoplasms) : The inhibitory role of Erbin in ERK signaling has been demonstrated