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MDM2 — TCHP

Text-mined interactions from Literome

Kubbutat et al., Cell Growth Differ 1999 : Degradation of the p53 tumor suppressor protein has been shown to be regulated by Mdm2
Wunderlich et al., Oncogene 2002 : Mdm2 , a major cellular regulator of the p53 tumor suppressor protein , is also closely involved in cell cycle and apoptosis
Okumura et al., Jpn J Cancer Res 2002 : Overexpression of the oncoprotein MDM2 , an important regulator of the p53 tumor suppressor protein , is often observed in breast cancer tissues and cell lines, particularly in those which express estrogen receptor alpha (ERalpha)
Yang et al., Cancer Cell 2005 : The p53 tumor suppressor protein is regulated by its interaction with HDM2 , which serves as a ubiquitin ligase ( E3 ) to target p53 for degradation
Kubbutat et al., Mol Cell Biol 1998 : The stability of the p53 tumor suppressor protein is regulated by interaction with Mdm2 , the product of a p53-inducible gene