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FOS — RPGR
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Zhai et al., Pain 1999
(Inflammation...) :
In awake rats, noxious
CRD induced
Fos expression in the lumbosacral spinal cord ... Both noxious and non-noxious
CRD induced
Fos in the lumbosacral spinal cord ... Pretreatment with MK-801 ( 0.5, 1.0, 5.0 mg/kg, i.p. ) dose-dependently attenuated noxious
CRD induced
Fos by 20-40 % ... Five mg/kg MK-801 attenuated non-noxious
CRD induced
Fos by 20 % ... These data suggest that the
induction of
Fos in the lumbosacral spinal cord by noxious and non-noxious
CRD is partially NMDA receptor mediated ... However, NMDA receptor activation contributes significantly more to noxious than non-noxious
CRD induced
Fos
Traub et al., Pain 2002
(Colitis) :
The laminar distribution of this
CRD induced
Fos suggests some of these neurons project to the parabrachial nucleus ( PBn ), an important relay for visceroceptive input from the spinal cord to higher order centers for nociceptive processing
Traub et al., Neuroscience 2002
(Pain) :
In the second part, the effects of the NMDA receptor antagonist dizocilpine maleate ( MK-801, 0-100 nmol, intrathecal ) on
CRD induced
Fos expression in the lumbosacral spinal cord were examined ... MK-801 dose-dependently attenuated noxious
CRD induced
Fos
Murphy et al., Physiol Behav 2009
(Pain) :
While no sex differences were noted in either the distribution of spino-PBn neurons or in
CRD induced
Fos expression, significantly greater Fos expression was noted specifically in spino-PBn neurons in males compared to females
Ait-Belgnaoui et al., Neurogastroenterol Motil 2009
(Dilatation, Pathologic...) :
The aims of the present study were to determine whether ( i ) stress induced visceral hyperalgesia modifies the expression of
Fos , a marker of general neuronal activation,
induced by
CRD , ( ii ) this activation can be modulated by L. farciminis treatment ... This study shows that PRS enhances
Fos protein expression
induced by
CRD at the spinal and supraspinal levels in rats
Duale et al., J Neurotrauma 2010
(Decerebrate State...) :
Hence our results imply that increased
CRD induced
c-Fos expression in the injured paradigm, prior to but not after PRV injection, further attenuates PRV-152 uptake, perhaps through changes in neuronal activity and/or innate neuro-immune responses
Traub et al., Neurosci Lett 1993
(Pain) :
Noxious
CRD induced both
c-Fos and c-Jun in the SPN, but not the IML
Traub et al., Neurosci Lett 1996
(Pain) :
Many cortical ( cingulate ; retrosplenial ; insular ; perirhinal, entorhinal ) and subcortical ( periaqueductal gray ; locus coeruleus ; lateral parabrachial area ; paraventricular, anterodorsal and centromedian thalamic nuclei ; lateral septal area ; dorsomedial hypothalamus ; cortical amygdala ; subiculum ) areas were labeled in the control rats, but significantly more
Fos was
observed in these areas following noxious
colorectal distention (CRD)
Traub et al., Brain Res 1995
(Pain) :
We have previously reported that repetitive, noxious
colorectal distention (CRD) induces
c-Fos in the lumbosacral spinal cord