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Fish et al., J Biol Chem 2005
:
Inhibition of histone deacetylase activity by trichostatin A increased acetylation of histones H3 and H4 at the eNOS proximal promoter in nonexpressing cell types and led to increased steady-state eNOS mRNA transcript levels
Gan et al., Biochem Biophys Res Commun 2006
:
Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells
Wang et al., Blood 2010
(Atherosclerosis) :
Adenoviral overexpression of a HDAC5 phosphorylation-defective mutant ( Ser259/Ser498 were replaced by Ala259/Ala498, HDAC5-S/A ), which shows resistance to flow induced nuclear export, suppressed flow mediated MEF2 transcriptional activity and expression of KLF2 and eNOS