◀ Back to SHC1
KDR — SHC1
Pathways - manually collected, often from reviews:
-
BioCarta vegf hypoxia and angiogenesis:
VEGF/VEGF R complex (VEGF-FLT4_KDR_FLT1)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
KEGG Focal adhesion:
EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB
→
SHC1/SHC2/SHC3/SHC4
(protein-protein, activation)
-
WikiPathways Focal Adhesion:
BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1
→
SHC1/SHC3
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
KDR
—
SHC1
(physical association, affinity chromatography technology)
Zanetti et al., Arterioscler Thromb Vasc Biol 2002*
-
IRef Biogrid Interaction:
KDR
—
SHC1
(physical association, affinity chromatography technology)
D'Angelo et al., Mol Endocrinol 1999*
-
IRef Hprd Interaction:
SHC1
—
KDR
(two hybrid)
Warner et al., Biochem J 2000*
-
IRef Intact Interaction:
KDR
—
SHC1
(association, coimmunoprecipitation)
Ratcliffe et al., Oncogene 2002*
-
IRef Intact Interaction:
KDR
—
SHC1
(physical association, pull down)
Zanetti et al., Arterioscler Thromb Vasc Biol 2002*
-
IRef Ophid Interaction:
KDR
—
SHC1
(aggregation, confirmational text mining)
Warner et al., Biochem J 2000*
-
IRef Ophid Interaction:
KDR
—
SHC1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Ratcliffe et al., Oncogene 2002
:
The Sck and
Shc SH2 domains, and not the PTB domain,
mediates its interactions with
KDR , as recombinant Sck SH2 domain binds to a tyrosine phosphorylated KDR 1175 derived synthetic peptide, but not to a peptide synthesized without tyrosine phosphate
Oshikawa et al., Am J Physiol Heart Circ Physiol 2012
(MAP Kinase Signaling System) :
Fractionation of caveolin enriched lipid raft demonstrates that
p66Shc plays a critical role in
VEGFR2 phosphorylation in caveolae/lipid rafts as well as downstream p38MAP kinase activation