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IL8 — PI3
Text-mined interactions from Literome
Schulte et al., FASEB J 2000
:
Invasin triggered
IL-8 production does not depend on invasin triggered uptake of bacteria, and is
independent of a functional
PI3-kinase
Al-Okla et al., Cell Microbiol 1999
:
However,
PI-3K activation is not
involved in
IL-8 release
Henriksen et al., J Immunol 2004
(Arteriosclerosis) :
Elafin and murine SLPI also
reduced endothelial
IL-8 release in response to oxidized low density lipoprotein, LPS, and TNF-alpha and macrophage TNF-alpha production in response to LPS
Cowburn et al., Eur J Immunol 2004
:
Inhibition of I kappa B-alpha phosphorylation,
PI3-kinase or ERK1/2 activation
blocked IL-8 release by both cytokines
Newcomb et al., J Biol Chem 2005
:
We examined the
role of
phosphatidylinositol (PI) 3-kinase in RV-induced
interleukin (IL)-8 expression ... Inhibition of
PI 3-kinase and Akt
attenuated RV39 induced NF-kappaB transactivation and
IL-8 expression
Wrann et al., J Immunol 2007
(Sepsis) :
In addition,
PI3K inhibition
resulted in strongly elevated TLR-4 mediated generation of IL-1beta and
IL-8 in neutrophils when these cells were co-stimulated with C5a
Syeda et al., J Cell Physiol 2008
(MAP Kinase Signaling System) :
The HNP induced
IL-8 production was
blocked by the Src tyrosine kinase inhibitor PP2, MEK1/2 inhibitor U0126, and the
phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002, but not by the JNK inhibitor SP600125 in both cell types
Tanaka et al., Biochem Biophys Res Commun 2008
:
The PAR2 triggered
IL-8 release was
suppressed by inhibitors of MEK ( U0126 ) or
PI3-kinase ( LY294002 ), and PAR2 stimulation indeed activated the downstream kinases, ERK and Akt
Yang et al., Microvasc Res 2009
(AIDS Dementia Complex) :
Inhibitors of STAT1, mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and
phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly
diminished IL-8- , IL-6-, and gp120 induced monocyte adhesion and migration across in vitro BBB models
He et al., Rheumatol Int 2011
(Arthritis, Rheumatoid) :
TNFa- or hypoxia induced secretion of VEGF and IL-8 and expression of HIF-1a were hampered by treatment with the PI3 kinase inhibitor LY294002, suggesting that inhibition of
PI3 kinase/Akt activation might
inhibit VEGF and
IL-8 secretion and HIF-1a expression induced by TNFa or hypoxia
Ivison et al., Mediators Inflamm 2010
(Inflammation) :
Release of the chemokine
IL-8 in response to flagellin
involves NF-?B, p38 MAP kinase, and
phosphatidylinositol 3-kinase (PI3K)
Lin et al., J Biol Chem 2011
:
In this study, we further investigated the
roles of Rac1,
phosphoinositide 3-kinase (PI3K) , and Akt in thrombin induced NF-?B activation and
IL-8/CXCL8 expression
Zhang et al., J Cell Physiol 2012
(Carcinoma, Non-Small-Cell Lung...) :
EGF stimulated
IL-8 production, phosphorylation of Akt and Erk, and cell proliferation and movement could be
inhibited by EGFR inhibitor ( Erlotinib ),
PI3K inhibitor ( GDC-0941 BEZ-235 and SHBM1009 ), and ERK1/2 inhibitor ( PD98059 )
Britschgi et al., Cancer Cell 2012
(Breast Neoplasms...) :
Mechanistically,
PI3K/mTOR inhibition
increased IRS1 dependent activation of JAK2/STAT5 and secretion of
IL-8 in several cell lines and primary breast tumors