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MDM2 — USP7

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: MDM2 — USP7 Meulmeester et al., Mol Cell 2005*
• IRef Bind_translation Interaction: USP7 — MDM2 (affinity chromatography technology) Meulmeester et al., Mol Cell 2005*
• IRef Biogrid Interaction: USP7 — MDM2 (direct interaction, pull down) Sheng et al., Nature structural & molecular biology 2006*
• IRef Biogrid Interaction: USP7 — MDM2 (association, x-ray crystallography) Sheng et al., Nature structural & molecular biology 2006*
• IRef Biogrid Interaction: USP7 — MDM2 (direct interaction, unspecified method) Sheng et al., Nature structural & molecular biology 2006*
• IRef Biogrid Interaction: USP7 — MDM2 (physical association, affinity chromatography technology) Lu et al., Cancer Cell 2007*
• IRef Biogrid Interaction: USP7 — MDM2 (physical association, affinity chromatography technology) Becker et al., Cell Death Differ 2007*
• IRef Biogrid Interaction: USP7 — MDM2 (physical association, affinity chromatography technology) Pereg et al., Mol Cell Biol 2006*
• IRef Biogrid Interaction: USP7 — MDM2 (direct interaction, unspecified method) Hu et al., PLoS Biol 2006*
• IRef Biogrid Interaction: USP7 — MDM2 (colocalization, biochemical) Hu et al., PLoS Biol 2006*
• IRef Biogrid Interaction: USP7 — MDM2 (association, x-ray crystallography) Hu et al., PLoS Biol 2006*
• IRef Biogrid Interaction: USP7 — MDM2 (direct interaction, pull down) Sarkari et al., J Mol Biol 2010*
• IRef Biogrid Interaction: USP7 — MDM2 (direct interaction, unspecified method) Sarkari et al., J Mol Biol 2010*
• IRef Biogrid Interaction: USP7 — MDM2 (physical association, affinity chromatography technology) Tang et al., Nat Cell Biol 2006
• IRef Biogrid Interaction: USP7 — MDM2 (direct interaction, pull down) Ma et al., Arch Biochem Biophys 2010*
• IRef Biogrid Interaction: USP7 — MDM2 (physical association, affinity chromatography technology) Song et al., EMBO J 2008
• IRef Dip Interaction: MDM2 — USP7 (direct interaction, isothermal titration calorimetry) Hu et al., PLoS Biol 2006*
• IRef Dip Interaction: MDM2 — USP7 (direct interaction, pull down) Sheng et al., Nature structural & molecular biology 2006*
• IRef Dip Interaction: MDM2 — USP7 (direct interaction, classical fluorescence spectroscopy) Sheng et al., Nature structural & molecular biology 2006*
• IRef Dip Interaction: MDM2 — USP7 (direct interaction, molecular sieving) Sheng et al., Nature structural & molecular biology 2006*
• IRef Dip Interaction: MDM2 — USP7 (direct interaction, x-ray crystallography) Sheng et al., Nature structural & molecular biology 2006*
• IRef Dip Interaction: MDM2 — USP7 (direct interaction, molecular sieving) Hu et al., PLoS Biol 2006*
• IRef Hprd Interaction: USP7 — MDM2 (in vitro) Meulmeester et al., Mol Cell 2005*, Sheng et al., Nature structural & molecular biology 2006*, Tang et al., Nat Cell Biol 2006, Lu et al., Cancer Cell 2007*
• IRef Hprd Interaction: USP7 — MDM2 (in vivo) Meulmeester et al., Mol Cell 2005*, Sheng et al., Nature structural & molecular biology 2006*, Tang et al., Nat Cell Biol 2006, Lu et al., Cancer Cell 2007*
• IRef Intact Interaction: Complex of MDM2-RASSF1-USP7 (association, anti bait coimmunoprecipitation) Song et al., EMBO J 2008
• IRef Intact Interaction: Complex of 17 proteins (association, anti bait coimmunoprecipitation) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: Complex of 16 proteins (association, anti bait coimmunoprecipitation) Song et al., EMBO J 2008
• IRef Intact Interaction: Complex of USP7-TP53-MDM2-MDM4 (association, anti bait coimmunoprecipitation) Meulmeester et al., Mol Cell 2005*
• IRef Intact Interaction: Complex of 50 proteins (association, anti tag coimmunoprecipitation) Coffill et al., EMBO Rep 2012
• IRef Intact Interaction: Complex of USP7-MDM2-MDM2-MDM2-DAXX-DAXX-USP7-DAXX-USP7 (association, anti tag coimmunoprecipitation) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: MDM2 — USP7 (direct interaction, x-ray crystallography) Sheng et al., Nature structural & molecular biology 2006*
• IRef Intact Interaction: MDM2 — USP7 (direct interaction, pull down) Sheng et al., Nature structural & molecular biology 2006*
• IRef Intact Interaction: MDM2 — USP7 (direct interaction, molecular sieving) Sheng et al., Nature structural & molecular biology 2006*
• IRef Intact Interaction: MDM2 — USP7 (physical association, anti bait coimmunoprecipitation) Lu et al., Cancer Cell 2007*
• IRef Intact Interaction: MDM2 — USP7 (physical association, pull down) Meulmeester et al., Mol Cell 2005*
• IRef Intact Interaction: MDM2 — USP7 (physical association, classical fluorescence spectroscopy) Sheng et al., Nature structural & molecular biology 2006*

Text-mined interactions from Literome

Li et al., Mol Cell 2004 (Bone Neoplasms) : We further show that this phenomenon occurs because HAUSP stabilizes Mdm2 in a p53 independent manner, providing an interesting feedback loop in p53 regulation ... Notably, HAUSP is required for Mdm2 stability in normal cells ; in HAUSP ablated cells, self-ubiquitinated-Mdm2 becomes extremely unstable, leading to indirect p53 activation
Tang et al., Nat Cell Biol 2006 : Daxx simultaneously binds to Mdm2 and the deubiquitinase Hausp, and it mediates the stabilizing effect of Hausp on Mdm2
Khoronenkova et al., Nucleic Acids Res 2011 : USP7 is involved in the cellular stress response by regulating Mdm2 and p53 protein levels following severe DNA damage