Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — HGF

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Davies et al., Anticancer Res 1999 (Neoplasm Invasiveness...) : Using immunoprecipitation, HGF/SF induced tyrosine phosphorylation of beta-catenin but not desmoplakin
Noë et al., Biochem Soc Symp 1999 (Neoplasm Invasiveness) : Scatter factor/hepatocyte growth factor ( SF/HGF ), on binding to its c-met tyrosine kinase receptor, can induce invasion through tyrosine phosphorylation of beta-catenin
Liu et al., FASEB J 2002 : GSK-3beta phosphorylation was strongly correlated with reductions in both HGF induced TER and enhanced beta-catenin immunoreactivity observed at cell-cell junctions
Müller et al., Exp Cell Res 2002 (Carcinoma...) : Hepatocyte growth factor (HGF) and epidermal growth factor (EGF) induce beta-catenin signaling under conditions where they stimulate cell motility
Liou et al., Molecular vision 2002 : HGF induced a MAP kinase dependent ARPE-19 cell migration, which is accompanied with a transient increase of c-jun expression and concomitant increases of MAP kinase activity, tyrosine phosphorylation of HGFR and beta-catenin, increased cytosolic levels of beta-catenin , and transactivation activity of beta-catenin
Dash et al., Cell Signal 2005 : We also found that both HGF treatment and pharmacological activation of beta-catenin leads to increased expression of inducible nitric oxide synthase (iNOS)
Zeng et al., Exp Cell Res 2006 : HGF induced Met-beta-catenin dissociation and nuclear translocation of beta-catenin , which was tyrosine-phosphorylation dependent ... All single or double-mutant transfected cells continued to show HGF induced nuclear translocation of FLAG-beta-catenin except the mutations affecting 654 and 670 simultaneously ( Y654/670F ), which coincided with the lack of formation of beta-catenin-TCF complex and DNA synthesis, in response to the HGF treatment ... In addition, the Y654/670F transfected cells also showed no phosphorylation of beta-catenin or dissociation from Met in response to HGF ... Thus, intact 654 and 670 tyrosine residues in beta-catenin are crucial in HGF mediated beta-catenin translocation, activation and mitogenesis
Peruzzi et al., Proc Natl Acad Sci U S A 2006 (Carcinoma, Renal Cell...) : We show that reconstitution of VHL expression in RCC cells repressed HGF stimulated beta-catenin tyrosyl phosphorylation, adherens junction disruption, cytoplasmic beta-catenin accumulation, and reporter gene transactivation in RCC cells
Lee et al., Eur Surg Res 2007 (Adenocarcinoma...) : The effects of HGF on the expression of E-cadherin/beta-catenin and MMP-7 at both the protein and mRNA levels were assessed in stomach cancer cells, NUGC-3 and MKN-28, and in cells in which the expression of MMP-7 was downregulated by transfection with a MMP-7 short hairpin RNA plasmid
Lee et al., Am J Physiol Lung Cell Mol Physiol 2008 : Inhibition of p42/p44 MAPK pathway blocked HGF mediated activation of beta-catenin gene transcription but not Akt activation, suggesting that p42/p44 MAPK acts in a parallel mechanism for beta-catenin activation
David et al., J Cell Sci 2008 : However, HGF , which also increases axon growth and branching, induces beta-catenin phosphorylation at Y142 and a nuclear localization
Previdi et al., Eur J Cancer 2010 (Bone Neoplasms...) : In 1833 cells, human and mouse HGF increased Met and beta-catenin tyrosine phosphorylation and expression in nuclear and perinuclear compartments, beta-catenin nuclear translocation via Kank and TOPFLASH transactivation
Hu et al., Anat Rec (Hoboken) 2010 (Ovarian Neoplasms) : Our data indicated that HGF leads to downregulation of E-cadherin, beta-catenin , and caveolin-1, disassembly of cell-cell contacts, and invasion and migration enhancement in human ovarian cancer cells
Balkovetz et al., J Biol Chem 1997 : We examined the effects of HGF on E-cadherin localization and interaction with beta-catenin in polarized Madin-Darby canine kidney ( MDCK ) cell monolayers grown on filters ... Coimmunoprecipitation of beta-catenin/E-cadherin complexes showed that the amount of E-cadherin associated with beta-catenin increased during the first 24 h of HGF treatment with a return to baseline values after 48 and 72 h. Metabolic labeling showed that HGF increased the synthetic rate of beta-catenin and the amount of newly synthesized E-cadherin associated with immunoprecipitated beta-catenin, with the peak effect occurring after 12 h of treatment and returning to baseline after 24 h. HGF treatment inhibited transcytosis of immunoglobulin A by the polymeric immunoglobulin receptor
Papkoff et al., Biochem Biophys Res Commun 1998 : WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells ... Both Wnt-1 and HGF/SF lead to nuclear accumulation of beta-catenin and activation of a LEF/Tcf responsive reporter gene
Grisendi et al., J Cell Physiol 1998 : The presence of HGF during the calcium switch caused increased tyrosine phosphorylation of beta-catenin