Lin et al., Reproductive biology and endocrinology : RB&E 2009
:
Leptin induces the activation of ERK1/2, p38 and JNK but only the ERK1/2 ( PD98059 ) and p38 ( SB203580 ) inhibitors attenuate the leptin induced inhibition of cAMP stimulated StAR protein expression and progesterone production
Thompson et al., HPB (Oxford) 2011
(Carcinoma, Hepatocellular...) :
Immunoblot analysis demonstrated that leptin significantly activated p42/p44-MAPK, p38-MAPK and STAT3 signalling in a time dependent manner
Rajapurohitam et al., Mol Cell Biochem 2012
(Hypertrophy) :
The ability of both angiotensin II- and endothelin-1 to increase leptin production in cardiomyocytes and the resultant hypertrophic response are mediated by NF-?B and dependent on p38 MAPK activation