◀ Back to CD8A
CD8A — HLA-B
Pathways - manually collected, often from reviews:
-
KEGG Cell adhesion molecules (CAMs):
HLA-A/HLA-B/HLA-C/HLA-E/HLA-F/HLA-G
→
CD8A/CD8B
(protein-protein, activation)
-
KEGG Cell adhesion molecules (CAMs):
HLA-A/HLA-B/HLA-C/HLA-E/HLA-F/HLA-G
→
CD8A/CD8B
(protein-protein, activation)
-
KEGG Antigen processing and presentation:
CD8A/CD8B
→
HLA-A/HLA-B/HLA-C/HLA-E/HLA-F/HLA-G
(protein-protein, binding/association)
-
Reactome Reaction:
HLA-B
→
CD8A
(reaction)
Kjer-Nielsen et al., Proc Natl Acad Sci U S A 2004, Arnett et al., Proc Natl Acad Sci U S A 2004, Rudolph et al., Annu Rev Immunol 2006
-
Reactome Reaction:
HLA-B
→
CD8A
(indirect_complex)
Kjer-Nielsen et al., Proc Natl Acad Sci U S A 2004, Arnett et al., Proc Natl Acad Sci U S A 2004, Rudolph et al., Annu Rev Immunol 2006
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Cheuk et al., J Immunol 2002
:
Expression of each HLA ( hyb ) molecule and
HLA-B27 ( nat ) /human beta(2)-microglobulin
led to peripheral
CD8 ( + ) T cell levels comparable with that for mice expressing a single H2-K ( b ) or H2-D ( b ) gene
Rohrlich et al., Int Immunol 2003
(Orthomyxoviridae Infections) :
Expression of the
HLA-B7 ( m alpha 3 ) molecules
resulted in a 3- to 4-fold increase in peripheral
CD8 ( + ) T lymphocyte numbers compared to H-2 Cl I-a ( -/- ) knockout mice
Ostrov et al., Proc Natl Acad Sci U S A 2012
(Drug Hypersensitivity) :
Abacavir adverse reactions were recently shown to be driven by drug-specific activation of cytokine producing, cytotoxic
CD8 ( + ) T cells that
required HLA-B*57 : 01 molecules for their function ; however, the mechanism by which abacavir induces this pathologic T-cell response remains unclear