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IL2 — TAT

Text-mined interactions from Literome

Kutsch et al., J Virol 2000 (HIV Infections) : Herein, we demonstrate that HIV-1 Tat ( 72aa ) is a potent inducer of MCP-1, interleukin-8 (IL-8), and IP-10 expression in astrocytes
Fortin et al., J Biol Chem 2004 (HIV Infections) : Both Nef and Tat are involved in this virus mediated enhancing effect on interleukin-2 promoter activity
Muckenfuss et al., Mol Immunol 2006 (MAP Kinase Signaling System) : These DNA elements were also induced by the viral transactivator protein (Tat) and expression of Tat was sufficient to activate IL-2 induction in stimulated cells
Hidalgo-Estévez et al., J Gen Virol 2006 : Moreover, intracellular Tat expression increased the binding of NFAT/AP-1 complexes to the interleukin 2 promoter without significantly altering NFAT- and AP-1 independent binding
Leung et al., Nature 1988 : The tat-I product also induces kappa B and the IL-2R alpha kappa B binding activity in transfected Jurkat T lymphoid leukaemia cells
Chirmule et al., J Virol 1995 : Tat inhibited the anti-CD3 monoclonal antibody induced IL-2 mRNA expression and IL-2 secretion but did not affect IL-2 receptor alpha-chain mRNA or protein expression on peripheral blood T cells
Westendorp et al., J Virol 1994 : Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells ... To investigate the effects of human immunodeficiency virus type 1 ( HIV-1 ) Tat on interleukin-2 (IL-2) expression, we used IL-2 promoter-chloramphenicol acetyltransferase constructs and IL-2 secreting Jurkat T cells as a model system ... The Tat mediated increase in IL-2 promoter activity could selectively be blocked by antisense tat or-unlike the analogous effect of human T-cell lymphotropic virus type 1 Tax-by cyclosporin A
Poggi et al., J Biol Chem 1998 : Here we demonstrate that Tat inhibits apoptotic body engulfment and interleukin-12 production by blocking extracellular calcium influx