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NFKBIA — TAT
Text-mined interactions from Literome
Blázquez et al., AIDS Res Hum Retroviruses 1999
:
Tat induces NF-kappaB binding to DNA as a
result of
IkappaBalpha phosphorylation and degradation, which depend on the intracellular redox state
Kumar et al., FEBS Lett 1999
:
PTPase inhibitors also blocked
HIV-tat induced nuclear transcription factor NF-kappaB activation and
IkappaBalpha degradation required for MMP-9 induction
Nicolini et al., J Neurochem 2001
:
Consistently,
Tat induced
IkappaBalpha degradation - an index of NF-kappaB activation - was not affected by free radical scavengers, but was prevented by an NF-kappaB-specific inhibitor
Kabouridis et al., J Immunol 2002
(MAP Kinase Signaling System) :
In contrast, exogenously added
TAT-srIkappaBalpha did not
inhibit IL-1beta induced activation of extracellular signal regulated kinase, c-Jun N-terminal kinase, or p38 mitogen activated protein kinases or the phosphorylation and degradation of endogenous
IkappaBalpha
Puca et al., J Biol Chem 2007
(Acquired Immunodeficiency Syndrome) :
Here, we report that
IkappaB-alpha negatively
regulates the HIV-1 expression and replication in an NF-kappaB independent manner by directly binding to
Tat , which results in the nuclear export and cytoplasmic sequestration of the viral transactivator
Lee et al., Exp Mol Med 2009
:
Tat-SOD inhibited LPS induced NF-kappaB DNA binding activity,
IkappaBalpha degradation and activation of MAP kinases
Beauparlant et al., J Virol 1996
:
Coexpression of
I kappa B alpha inhibited
Tat-TNF-alpha activation of HIV LTR in a dose dependent manner