Chen et al., Kidney Int 2006
(Uremia) :
The results demonstrate that the cyclic AMP ( cAMP ) /protein kinase A (PKA) , but not protein kinase C, signaling pathway is involved in uremic serum induced RUNX2 expression and ALP activity in BVSMCs
Rey et al., Bone 2007
(MAP Kinase Signaling System) :
Activation of p38 is cAMP-PKA dependent and mediates PTH induced stimulation of ALP which plays a critical role for the calcification of the bone matrix