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SETD2 — TLR4

Text-mined interactions from Literome

Nishi et al., Antioxid Redox Signal 2008 : LPS induced ROS generation and HIF-1 activation required the expression of Toll-like receptor 4 or myeloid differentiation factor (MyD) 88, thus providing a molecular basis for the selective activation of HIF-1 in differentiated THP-1 cells
Kim et al., Immunology 2010 (Anoxia) : To determine the underlying mechanism, we investigated the role of hypoxia-inducible factor 1 (HIF-1) in the regulation of TLR4 expression
Riddell et al., PloS one 2012 (Neovascularization, Pathologic...) : Peroxiredoxin 1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1a
Shakespear et al., J Biol Chem 2013 (Inflammation) : Thus, Hdac7-u positively regulates HIF-1a dependent TLR signaling in macrophages, whereas an interaction with CtBP1 likely prevents Hdac7-s from exerting this effect