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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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MMP7 — PRG2

Text-mined interactions from Literome

Homandberg et al., Frontiers in bioscience : a journal and virtual library 1999 (Arthritis, Rheumatoid...) : The Fn-fs up-regulate matrix metalloproteinase ( MMP ) expression, significantly enhance degradation and loss of proteoglycan ( PG ) from cartilage and temporarily suppress PG synthesis, all events observed in OA
Haro et al., J Clin Invest 2000 (Bone Resorption...) : Using macrophages isolated from MMP-null mice, we report that macrophage produced MMP-7 was required for proteoglycan degradation, loss of wet weight, and macrophage infiltration of cocultured discs
Sabatini et al., Osteoarthritis Cartilage 2002 : This study shows that PPARgamma agonists inhibit cytokine induced proteoglycan degradation mediated by both aggrecanase and MMP
Homandberg et al., Biochem J 1997 : Whereas a 1 nM concentration of an N-terminal 29 kDa fibronectin fragment ( Fn-f ) increases the proteoglycan ( PG ) content of cartilage without induction of matrix metalloproteinases ( MMPs ), 0.1-1 microM Fn-f temporarily suppresses PG synthesis and enhances MMP release