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MMP7 — PRG2
Text-mined interactions from Literome
Homandberg et al., Frontiers in bioscience : a journal and virtual library 1999
(Arthritis, Rheumatoid...) :
The Fn-fs up-regulate
matrix metalloproteinase ( MMP ) expression, significantly
enhance degradation and loss of
proteoglycan ( PG ) from cartilage and temporarily suppress PG synthesis, all events observed in OA
Haro et al., J Clin Invest 2000
(Bone Resorption...) :
Using macrophages isolated from MMP-null mice, we report that macrophage produced
MMP-7 was
required for
proteoglycan degradation, loss of wet weight, and macrophage infiltration of cocultured discs
Sabatini et al., Osteoarthritis Cartilage 2002
:
This study shows that PPARgamma agonists inhibit cytokine induced
proteoglycan degradation
mediated by both aggrecanase and
MMP
Homandberg et al., Biochem J 1997
:
Whereas a 1 nM concentration of an N-terminal 29 kDa fibronectin fragment ( Fn-f ) increases the
proteoglycan ( PG ) content of cartilage without induction of matrix metalloproteinases ( MMPs ), 0.1-1 microM Fn-f temporarily suppresses PG synthesis and
enhances MMP release