Gene interactions and pathways from curated databases and text-mining

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MAPK3 — SOS1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Weng et al., Hum Mol Genet 2001 (Breast Neoplasms) : PTEN inhibits insulin stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
Shindo et al., J Gastroenterol 2006 (Wounds and Injuries) : ( 1 ) SOS activated IkappaB-alpha, but it did not activate ERK1/2 MAPK
Tartaglia et al., Molecular syndromology 2010 : SHP2 ( encoded by PTPN11 ), SOS1 , BRAF, RAF1 and MEK1 positively contribute to RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations ... SHP2 ( encoded by PTPN11 ), SOS1 , BRAF, RAF1 and MEK1 positively contribute to RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations
Welham et al., J Biol Chem 1995 (Leukemia, Erythroblastic, Acute...) : In lymphohemopoietic cells, IL-13, IL-4, and insulin failed to induce increased tyrosine phosphorylation of Shc, or its association with grb2, modification of Sos1 , or activation of erk-1 and erk-2 mitogen activated protein kinases, suggesting that p170 mediates downstream pathways distinct from those mediated by IRS-1
Ming et al., Nature 1994 : Activation of p42mapk/p44mapk is triggered by sequential activation of the GDP-GTP exchange factor Sos , the GTP binding protein p21ras, and protein kinases p74raf and p47mek ( refs 7-10 )
Corbalan-Garcia et al., Mol Cell Biol 1996 : Previous studies have demonstrated that growth factor induced Sos phosphorylation occurs at the C-terminal region of the protein and is mediated , in part, by mitogen activated protein ( MAP ) kinase
Lopez-Ilasaca et al., Science 1997 : The tyrosine kinase class of receptors induces mitogen activated protein kinase ( MAPK ) activation through the sequential interaction of the signaling proteins Grb2, Sos , Ras, Raf, and MEK
Della Rocca et al., J Biol Chem 1997 : Erk1/2 phosphorylation in response to alpha1B-AR stimulation is also attenuated by coexpression of N17-Ras, SOS-Pro , or DeltaN-Raf, but not by coexpression of betaARK1ct or by pretreatment with pertussis toxin
Nimnual et al., Science 1998 : Ras mediated activation of DH-PH-Sos did not require activation of mitogen activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase