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S100B — VEGFA

Text-mined interactions from Literome

Kim et al., J Ethnopharmacol 2007 : In this study, the effect of KIOM-79 on HG or S100b induced VEGF expression was investigated using 3- ( 4,5-dimethylthiazol-2-yl ) -2,5-diphenyl tetrazolium bromide ( MTT ) assay, RT-PCR, ELISA, and Western blot on human RPE cells ... HG or S100b induced an increase in expression of VEGF at both mRNA and protein levels ( p < 0.05 ; p < 0.01 versus control )
Tsoporis et al., J Mol Cell Cardiol 2012 (Myocardial Infarction...) : S100B-RAGE dependent VEGF secretion by cardiac myocytes induces myofibroblast proliferation ... In RAGE overexpressing myocytes, S100B ( 100 nM ) resulted in increases in VEGF mRNA, VEGF protein, VEGF secretion, and activation of the transcription factor NF-?B ... In myocytes expressing dominant negative RAGE, S100B did not induce VEGF mRNA, VEGF protein, VEGF secretion or NF-?B activation ... Together these data demonstrate that secreted VEGF by cardiac myocytes in response to S100B via RAGE ligation induces myofibroblast proliferation potentially contributing to scar formation observed in infarcted myocardium