◀ Back to SGK1
RELA — SGK1
Text-mined interactions from Literome
Zhang et al., Cancer Res 2005
(Breast Neoplasms) :
Serum induced
SGK or increased expression of SGK
activated NF-kappaB transcriptional activity, whereas small interference RNA to SGK blocked NF-kappaB activity ... Coexpression of
SGK and IKKbeta significantly
increased the activation of
NF-kappaB ( versus expression of IKKbeta alone ) ... Expression of dominant negative IKKbeta K44A, IkappaBalpha AA, and kinase-dead SGK ( 127KM ) blocked the ability of
SGK to
stimulate NF-kappaB activity, suggesting that IKKbeta is a target of SGK
Terada et al., J Am Soc Nephrol 2008
(Fibrosis) :
In primary cultures of rat mesangial cells, aldosterone stimulated the expression, phosphorylation, and kinase activity of SGK1, as well as
SGK1 dependent
NF-kappaB activity
Tai et al., J Biol Chem 2009
:
Furthermore,
SGK1 enhanced
nuclear factor kappaB (NF-kappaB) activity and up-regulated N-methyl-d-aspartate receptor NR2A and NR2B expression through activation of IKKalpha at Thr-23 and Ser-180, and these two residues play an equally important role in mediating these effects of SGK1 ... Although SGK1 does not phosphorylate IKKbeta, IKKbeta activity is still required for IKK complex activation and for
SGK1 phosphorylation and
activation of
NF-kappaB ... In addition,
SGK1 increased the acetylation of NF-kappaB through phosphorylation of p300 at Ser-1834, and this also
leads to
NF-kappaB activation and NR2A and NR2B expression