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CD4 — IFIT1
Text-mined interactions from Literome
Van Drenth et al., J Immunol 2000
:
Using murine T cell hybridomas transfected to express native or mutated forms of CD4, it was determined that
IL-16/CD4 induces a
p56 ( lck ) -dependent inhibitory signal for CXCR4, which is independent of its tyrosine catalytic activity
Sorice et al., Glycoconj J 2000
:
The immunoprecipitation with anti-GM3 revealed the presence of a 58kDa band immunostained with anti-CD4 Ab, suggesting that the
GM3-CD4 interaction does not
require its association with
p56Ick
Mazerolles et al., J Immunol 1996
:
Phosphatidylinositol 3-kinase participates in
p56 ( lck )
/CD4 dependent down-regulation of LFA-1 mediated T cell adhesion ... Here we show that binding of these ligands to
CD4 induced the activation of the tyrosine kinase
p56 ( lck ) associated with CD4 and also the lipid kinase phosphatidylinositol-3 kinase ( PI3-kinase ) associated with the CD4-p56 ( lck ) complex in the HUT78 cell line
Cruikshank et al., J Immunol 1996
:
The binding of IL-16 to
CD4 results in activation of
p56 ( lck ), whose adaptor function is essential for the chemotactic response
Kaneko et al., Clin Exp Immunol 1997
(HIV Infections) :
On the other hand, inhibition of the mixed lymphocyte reaction (MLR) in CD4+ T cells by gp120, which may be related to gp120 mediated down-regulation of
CD4 expression on T cells and
activation of protein tyrosine kinase
p56 ( lck ) in CD4+ T cells, was observed even in the absence of macrophage derived TNF-alpha induced by gp120
Moutouh et al., J Virol 1998
(HIV Infections) :
These observations demonstrate that
CD4 signaling mediates HIV induced apoptosis by a mechanism independent of Fas-Fas ligand interaction, does not
require p56 ( lck ) signaling, and may involve a critical region for CD4 dimerization