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Leverkus et al., J Invest Dermatol 2003
(Dermatitis) :
By employing receptor-specific blocking antibodies we demonstrate that TRAIL receptor 1 plays the primary role in mediating caspase activation and apoptosis in HaCaT cells
Engels et al., Mol Cell Biol 2005
(Breast Neoplasms) :
Interestingly, neutralization of TRAIL receptor 2 (TRAIL-R2), but not TRAIL-R1 , impaired apoptosis in a caspase-10 dependent manner, indicating that caspase-10 enhances TRAIL-R2 induced cell death
Mazumdar et al., PloS one 2012
:
Gelsolin modulation of cell death using this fragment involved upregulation of TRAIL-R1 and TRAIL-R2, and involved caspase 3 activation by extrinsic pathway