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CBL — KLK3

Text-mined interactions from Literome

Liu et al., Mol Cell Biol 2002 : Insulin stimulated phosphorylation of tyrosine 618 in APS is necessary for its association with c-Cbl and the subsequent tyrosine phosphorylation of Cbl by the insulin receptor in both 3T3-L1 adipocytes and CHO-IR cells ... Overexpression of the APS/Y ( 618 ) F mutant in 3T3-L1 adipocytes blocked the insulin stimulated tyrosine phosphorylation of endogenous Cbl and binding to Crk
Ahn et al., J Biol Chem 2004 : Taken together, these results indicate that APS plays a central role in recruiting both CAP and c-Cbl to the insulin receptor after insulin stimulation and is necessary and sufficient for the insulin stimulated phosphorylation of c-Cbl , whereas SH2-Balpha may provide an alternative pathway for the recruitment of CAP